Propofol is a widely used intravenous anesthetic agent known for its rapid onset and short duration of action. It is commonly used for induction and maintenance of general anesthesia, sedation for procedures, and sedation in the intensive care unit (ICU). Due to its potency, propofol dosage must be carefully titrated based on the patient’s age, weight, medical condition, and the procedure being performed.
Propofol is a lipid-soluble compound that acts by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA), producing sedative and hypnotic effects. Its rapid onset of action and short half-life make it ideal for procedures requiring quick sedation and rapid recovery. Propofol can induce general anesthesia before surgery or provide prolonged sedation for patients in the ICU, among other uses 1,2.
Propofol is commonly used to induce anesthesia in both adults and children. The recommended induction dose for healthy adults is 1.5 to 2.5 mg/kg administered intravenously over 20-30 seconds. The exact dose depends on individual factors such as premedication, age, and health status. Propofol dosage is typically adjusted down for elderly patients who are usually more sensitive. The induction dose for children ranges from 2.5 to 3.5 mg/kg, depending on age and physical condition.
Once general anesthesia has been induced, propofol can be used to maintain it. Maintenance doses are administered either through continuous infusion or intermittent boluses. Continuous infusion is generally initiated at 100 to 200 mcg/kg/min; for intermittent boluses, 20-50 mg can be administered as needed. In contrast, maintenance infusion rates for children are generally higher, between 125 and 300 mcg/kg/min due to their faster metabolism.
For procedural sedation, sedation typically begins with an initial bolus of 0.5 to 1 mg/kg followed by maintenance doses of 25 to 75 mcg/kg/min through infusion. The total propofol dosage depends on the depth and duration of sedation needed. For older adults however, initial bolus doses should be reduced by 20-30%, and maintenance infusion should be titrated carefully to avoid excessive sedation.
Finally, for long-term sedation in ICU patients, propofol is administered as a continuous infusion. Infusion rates range from 5 to 50 mcg/kg/min for maintaining light to moderate sedation. Doses should be adjusted based on the patient’s response and depth of sedation required 3,4.
Though propofol is safe, effective, and widely used, it is associated with some side effects. It may lead to hypotension after induction due to its vasodilatory properties. In addition, especially at higher doses, propofol can cause significant respiratory depression, requiring airway management 1,5.
References
1. Propofol – StatPearls – NCBI Bookshelf. Available at: https://www.ncbi.nlm.nih.gov/books/NBK430884/.
2. Aboian, M., Johnson, J. M. & Thomas Ginat, D. Propofol. Neuroimaging Pharmacopoeia, Second Ed. 281–283 (2023). doi:10.1007/978-3-031-08774-5_40
3. Propofol Dosage Guide + Max Dose, Adjustments – Drugs.com. Available at: https://www.drugs.com/dosage/propofol.html.
4. Diprivan (propofol) dosing, indications, interactions, adverse effects, and more. Available at: https://reference.medscape.com/drug/diprivan-propofol-343100. 5. Propofol (Intravenous Route) Side Effects – Mayo Clinic. Available at: https://www.mayoclinic.org/drugs-supplements/propofol-intravenous-route/side-effects/drg-20488192?p=1.